Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015282 | 0.83 | ALDH1A1 (0.40) | ALDH1A1POLBL3MBTL1KDM4EMAPT | |
| SCHEMBL24249958 | 0.79 | TLR4 (0.49) | ALDH1A1POLBL3MBTL1GAAKMT2A | |
| SCHEMBL1141761 | 0.79 | TLR4 (0.49) | ALDH1A1POLBL3MBTL1GAAKMT2A | |
| SCHEMBL17118109 | 0.79 | TLR4 (0.49) | ALDH1A1POLBL3MBTL1GAAKMT2A | |
| SCHEMBL17048600 | 0.75 | MMP2 (0.33) | MAPT | |
| SCHEMBL17110215 | 0.75 | SERPINA6 (0.34) | MAPK1ALDH1A1KMT2ALMNANPSR1 | |
| SCHEMBL3780480 | 0.69 | MAPK1 (0.41) | MAPK1ALDH1A1NFKB1NFKB2RELA | |
| SCHEMBL9163502 | 0.69 | DDB1 (0.48) | MAPK1 | |
| SCHEMBL6283782 | 0.68 | MAPK1 (0.46) | MAPK1ALDH1A1POLBGAAKMT2A | |
| SCHEMBL31506648 | 0.68 | MAPK1 (0.35) | MAPK1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110278711-B | Tricyclosulfones as rory modulators | 百时美施贵宝公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-110049985-B | Heterocyclic sulfones as ROR gamma modulators | 百时美施贵宝公司 | 2022-05-31 | — | — | CN | disclosed |
| US-10934286-B2 | Heterocyclic sulfones as ROR gamma modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-03-02 | — | — | US | disclosed |
| EP-3541786-B1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-05 | — | — | EP | disclosed |
| US-10435369-B2 | Tricyclic sulfones as ROR gamma modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190300523-A1 | HETEROCYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2019-10-03 | — | — | US | disclosed |
| US-20180127368-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2018-05-10 | — | — | US | disclosed |
| US-20180127368-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2018-05-10 | — | — | US | disclosed |
| WO-2018071620-A1 | HETEROCYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10435369-B2 | Tricyclic sulfones as ROR gamma modulators | RORC, RORB, RORA | MAPK1 2113/4885ALDH1A1 991/4885NFKB1 605/4885 |
| US-20190300523-A1 | HETEROCYCLIC SULFONES AS ROR GAMMA MODULATORS | RORC, RORB, RORA | MAPK1 1823/4885ALDH1A1 788/4885NFKB1 545/4885 |
| US-10934286-B2 | Heterocyclic sulfones as ROR gamma modulators | RORC, RORB, RORA | MAPK1 1823/4885ALDH1A1 788/4885NFKB1 545/4885 |
| US-20180127368-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | RORC, RORB, RORA | MAPK1 2113/4885ALDH1A1 991/4885NFKB1 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.