Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006939 | 0.95 | L3MBTL1 (0.37) | LMNAMAPTALDH1A1ALOX12MAPK1 | |
| SCHEMBL2001504 | 0.94 | FAAH (0.35) | LMNAMAPTALDH1A1ALOX12MAPK1 | |
| SCHEMBL2008605 | 0.93 | LMNA (0.41) | LMNAMAPTALDH1A1ALOX12MAPK1 | |
| SCHEMBL2002620 | 0.92 | PLA2G2A (0.37) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL2002148 | 0.91 | LMNA (0.34) | LMNAMAPTMAPK14MEN1KMT2A | |
| SCHEMBL2007854 | 0.91 | FAAH (0.35) | MAPTALDH1A1ALOX12MAPK14MEN1 | |
| SCHEMBL2005893 | 0.89 | SCD (0.34) | LMNAMAPTALDH1A1ALOX12MAPK1 | |
| SCHEMBL2004149 | 0.89 | GRM5 (0.41) | LMNAMAPTALDH1A1ALOX12VDR | |
| SCHEMBL1999738 | 0.88 | CYP2C9 (0.39) | LMNAMAPTALDH1A1ALOX12MAPK1 | |
| SCHEMBL2003287 | 0.85 | LMNA (0.34) | LMNAMAPTALDH1A1ALOX12MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |