Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3910119 | 0.81 | TRPA1 (0.44) | L3MBTL1HPGDALDH1A1LMNAMAPT | |
| SCHEMBL15257400 | 0.79 | AOC2 (0.50) | L3MBTL1HPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL791960 | 0.79 | SMN1; SMN2 (0.55) | HSD17B10LMNASMN1; SMN2TRPA1MTNR1A | |
| SCHEMBL21970424 | 0.79 | ALDH1A1 (0.38) | TDP1HPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL28948151 | 0.79 | KMT2A (0.41) | TDP1KMT2AALOX15 | |
| SCHEMBL1255238 | 0.78 | PPARG (0.39) | HPGDALDH1A1ALOX15MAPK1KDM4E | |
| SCHEMBL20084566 | 0.77 | ALDH1A1 (0.40) | L3MBTL1TDP1HPGDKMT2AALDH1A1 | |
| SCHEMBL29954244 | 0.76 | LIPE (0.54) | HPGDALDH1A1ALOX15MAPK1KDM4E | |
| SCHEMBL28479323 | 0.76 | L3MBTL1 (0.51) | L3MBTL1HPGDALDH1A1HSD17B10MAPT | |
| SCHEMBL919356 | 0.76 | ADRA2A (0.36) | HPGDALDH1A1ALOX15MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |