Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91357 | 0.81 | L3MBTL1 (0.34) | RAPGEF4 | |
| SCHEMBL18957772 | 0.81 | RAPGEF4 (0.39) | RAPGEF4 | |
| SCHEMBL19833099 | 0.77 | ESR1 (0.31) | — | |
| SCHEMBL17552753 | 0.77 | RIPK1 (0.33) | — | |
| SCHEMBL13550132 | 0.74 | RAPGEF4 (0.38) | RAPGEF4 | |
| SCHEMBL22024000 | 0.73 | ACHE (0.44) | — | |
| SCHEMBL10256479 | 0.73 | ALDH1A1 (0.40) | RAPGEF4 | |
| SCHEMBL19493461 | 0.72 | RAPGEF4 (0.33) | RAPGEF4 | |
| SCHEMBL21994330 | 0.71 | RAPGEF4 (0.35) | RAPGEF4 | |
| SCHEMBL22914917 | 0.70 | ALDH1A1 (0.42) | RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180111931-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA PHARMACEUTICALS LP | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111931-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | RAPGEF4 4380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.