Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 11/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21030615 | 0.82 | PLAU (0.47) | SSTR4KCNJ5KCNJ3LMNACYP2C9 | |
| SCHEMBL24441084 | 0.81 | SSTR4 (0.38) | SSTR4LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL4573329 | 0.79 | SSTR4 (0.40) | SSTR4LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL23032774 | 0.79 | CHRNB2 (0.55) | — | |
| SCHEMBL18600902 | 0.79 | APP (0.54) | KCNJ5KCNJ3APPLMNACYP2C9 | |
| SCHEMBL20086562 | 0.78 | GABRA1 (0.39) | KCNJ5KCNJ3APPLMNACYP2C9 | |
| SCHEMBL18727047 | 0.78 | SSTR4 (0.42) | SSTR4LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL17055786 | 0.76 | AGBL2 (0.46) | SSTR4APPGAA | |
| SCHEMBL19229872 | 0.75 | SSTR4 (0.49) | SSTR4LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL6954046 | 0.75 | SMN1; SMN2 (0.47) | SSTR4LMNACYP2C9TSHRAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |
| US-10421751-B2 | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | LYCERA CORPORATION (US) | 2019-09-24 | — | — | US | disclosed |
| US-20180111922-A1 | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATEMENT OF DISEASE | LYCERA CORPORATION | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111922-A1 | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATEMENT OF DISEASE | RORB, RORA, RORC | SSTR4 786/4885KCNJ5 1204/4885KCNJ3 2155/4885 |
| US-10421751-B2 | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | RORB, RORA, RORC | SSTR4 983/4885KCNJ5 1251/4885KCNJ3 2020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.