Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ERN1 | O75460 | 6/20 | 0.50 |
| ▸ | XDH | P47989 | 3/20 | 0.48 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | BLVRB | P30043 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278447 | 0.86 | ERN1 (0.55) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL454793 | 0.84 | CDC7 (0.59) | KDM4EALDH1A1KMT2A | |
| SCHEMBL29627451 | 0.84 | CDC7 (0.59) | KDM4EALDH1A1KMT2A | |
| SCHEMBL12095197 | 0.82 | ERN1 (0.58) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL27795018 | 0.81 | RAB9A (0.56) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL12454256 | 0.81 | ERN1 (0.42) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL8867920 | 0.80 | RAB9A (0.61) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL15130562 | 0.79 | ERN1 (0.47) | ERN1 | |
| SCHEMBL12970384 | 0.79 | RAB9A (0.60) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL1356995 | 0.78 | XDH (0.70) | RAB9AKDM4EGAASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110824067-B | Method for detecting genotoxic impurities in febuxostat | 天津药物研究院有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-111499593-A | Synthesis process of febuxostat | 峨眉山宏昇药业股份有限公司 | 2020-08-07 | — | — | CN | disclosed |
| WO-2012073259-A1 | NOVEL PROCESS FOR THE PREPARATION OF FEBUXOSTAT | INDOCO REMEDIES LIMITED (IN) | 2012-06-07 | — | — | WO | disclosed |
| WO-2011073617-A1 | PROCESSES FOR THE PREPARATION OF FEBUXOSTAT AND SALTS THEREOF | CIPLA LIMITED (IN) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011066803-A1 | PREPARATION METHOD OF INTERMEDIATE OF FEBUXOSTAT | 重庆医药工业研究院有限责任公司 (CN) | 2011-06-09 | — | — | WO | disclosed |