Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | XDH | P47989 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | BLVRB | P30043 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27838195 | 0.86 | CDC7 (0.57) | KDM4EGAAALDH1A1KMT2A | |
| SCHEMBL31534636 | 0.86 | CDC7 (0.57) | KDM4EGAAALDH1A1KMT2A | |
| SCHEMBL12133611 | 0.81 | XDH (0.68) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL2009745 | 0.81 | RAB9A (0.59) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL8867920 | 0.77 | RAB9A (0.61) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL12095197 | 0.76 | ERN1 (0.58) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL12970384 | 0.76 | RAB9A (0.60) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL438271 | 0.75 | XDH (0.68) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL21156699 | 0.74 | RAB9A (0.69) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL2011167 | 0.74 | RAB9A (0.79) | RAB9AKDM4EGAASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109320474-A | A kind of preparation method of Febustat | 昆明源瑞制药有限公司 | 2019-02-12 | — | — | CN | claimed |
| CN-109320474-A | A kind of preparation method of Febustat | 昆明源瑞制药有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-109320474-A | A kind of preparation method of Febustat | 昆明源瑞制药有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-102964313-B | Synthetic method of febuxostat | ZHOU GUANGLIAN | 2015-04-29 | — | — | CN | disclosed |
| CN-101665471-B | Preparation method of febuxostat intermediate | UNIV CHINA PHARMA | 2011-08-10 | — | — | CN | disclosed |
| CN-101665471-A | Preparation method of febuxostat intermediate | UNIV CHINA PHARMA | 2010-03-10 | — | — | CN | disclosed |