Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999528 | 0.94 | ALOX5 (0.37) | MEN1MAPTALOX15TSHRKMT2A | |
| SCHEMBL2001753 | 0.93 | FAAH (0.44) | MEN1MAPTALOX15ALOX12KMT2A | |
| SCHEMBL2005326 | 0.91 | MEN1 (0.43) | MEN1CYP3A4MAPTALOX15TSHR | |
| SCHEMBL2008226 | 0.90 | ALDH1A1 (0.41) | MEN1CYP3A4KMT2AHDAC1HDAC6 | |
| SCHEMBL2005733 | 0.90 | MEN1 (0.45) | MEN1CYP3A4MAPTTSHRKMT2A | |
| SCHEMBL2006262 | 0.90 | CYP2C9 (0.40) | CYP3A4MAPTTSHRALOX12KMT2A | |
| SCHEMBL2000331 | 0.90 | PTGES2 (0.41) | MEN1CYP3A4MAPTALOX15TSHR | |
| SCHEMBL2006132 | 0.90 | ALOX5AP (0.43) | MEN1CYP3A4MAPTTSHRKMT2A | |
| SCHEMBL2004214 | 0.88 | CCR9 (0.37) | MEN1CYP3A4MAPTALOX15TSHR | |
| SCHEMBL2003811 | 0.88 | FAAH (0.41) | MEN1CYP3A4MAPTALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |