Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010345 | 0.94 | MEN1 (0.38) | ALOX5ALOX5APMAPTLMNAMEN1 | |
| SCHEMBL2004508 | 0.92 | MAPT (0.42) | ALOX5APMAPTPKMGAAALDH1A1 | |
| SCHEMBL2004090 | 0.90 | PTGES2 (0.40) | ALOX5ALOX5APMAPTPKMGAA | |
| SCHEMBL2001753 | 0.90 | FAAH (0.44) | ALOX5ALOX5APMAPTGAAALDH1A1 | |
| SCHEMBL2003317 | 0.90 | L3MBTL1 (0.38) | MAPTALDH1A1QPCTLMNAKMT2A | |
| SCHEMBL2002457 | 0.89 | ALOX5 (0.36) | ALOX5ALOX5APMAPTPKMGAA | |
| SCHEMBL2004890 | 0.89 | FAAH (0.39) | ALOX5ALOX5APMAPTPKMGAA | |
| SCHEMBL2008226 | 0.88 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2005733 | 0.88 | MEN1 (0.45) | ALOX5ALOX5APMAPTPKMALDH1A1 | |
| SCHEMBL2006132 | 0.87 | ALOX5AP (0.43) | ALOX5ALOX5APMAPTPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |