Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010877 | 0.90 | L3MBTL1 (0.48) | NPC1RAB9AL3MBTL1MAPTTDP1 | |
| SCHEMBL10150652 | 0.89 | THRB (0.50) | THRBRAB9AMAPTTDP1ALDH1A1 | |
| SCHEMBL2015522 | 0.89 | BCL2 (0.42) | THRBNPC1RAB9AL3MBTL1TDP1 | |
| SCHEMBL1979905 | 0.80 | P2RX7 (0.43) | — | |
| SCHEMBL10150960 | 0.79 | PDE10A (0.42) | THRBNPC1MAPTLMNA | |
| SCHEMBL1975060 | 0.78 | PPARG (0.40) | ALDH1A1LMNA | |
| SCHEMBL10150590 | 0.73 | PDE10A (0.42) | THRBMAPTLMNA | |
| SCHEMBL1973915 | 0.69 | PPARG (0.37) | RAB9A | |
| SCHEMBL10150961 | 0.67 | PPARG (0.40) | LMNA | |
| SCHEMBL1973525 | 0.65 | FAAH (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072691-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | disclosed |