Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113649 | 0.91 | MEN1 (0.37) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL20113995 | 0.80 | FGFR4 (0.35) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL20113637 | 0.72 | GRM1 (0.32) | NOS2 | |
| SCHEMBL20113675 | 0.71 | ALDH1A1 (0.34) | ALDH1A1LMNA | |
| SCHEMBL20113671 | 0.70 | GLP1R (0.33) | HPGDALDH1A1 | |
| SCHEMBL20113653 | 0.68 | CCR1 (0.38) | MEN1KMT2AHPGDALDH1A1TYR | |
| SCHEMBL27947021 | 0.67 | TLR8 (0.61) | KMT2AHPGDALDH1A1TLR8MAPT | |
| SCHEMBL20113643 | 0.66 | KDM4E (0.37) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4167074 | 0.66 | MEN1 (0.52) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL20113662 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |