Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 10/20 | 0.41 |
| ▸ | PTGES | O14684 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002364 | 0.93 | MAPT (0.41) | PTGES2PTGESMEN1KMT2ATBXAS1 | |
| SCHEMBL2006683 | 0.92 | MAPK1 (0.47) | PTGES2FAAHMEN1HTTKMT2A | |
| SCHEMBL2008741 | 0.91 | PTGES2 (0.44) | PTGES2PTGESFAAHMEN1HTT | |
| SCHEMBL2006137 | 0.91 | MAPT (0.42) | PTGES2PTGESMEN1KMT2ATBXAS1 | |
| SCHEMBL2002347 | 0.90 | PPARG (0.37) | KDM4EMITFALDH1A1LMNAMAPT | |
| SCHEMBL2002253 | 0.90 | PLA2G2A (0.46) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL2006816 | 0.89 | LMNA (0.42) | PTGES2PTGESMEN1KMT2AKDM4E | |
| SCHEMBL2005819 | 0.89 | MEN1 (0.43) | PTGES2PTGESFAAHMEN1HTT | |
| SCHEMBL2002059 | 0.89 | FAAH (0.49) | PTGES2PTGESFAAHMEN1HTT | |
| SCHEMBL2002574 | 0.89 | FAAH (0.42) | PTGES2PTGESFAAHMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |