Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002364 | 0.94 | MAPT (0.41) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL2000262 | 0.92 | MAPK1 (0.48) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2003185 | 0.91 | PTGES2 (0.41) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2011368 | 0.91 | PTGES2 (0.41) | MAPTALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL2006816 | 0.90 | LMNA (0.42) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2005140 | 0.90 | L3MBTL1 (0.41) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2002253 | 0.89 | PLA2G2A (0.46) | MAPTPKMALDH1A1LMNAMEN1 | |
| SCHEMBL2002177 | 0.88 | MAPT (0.38) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2004278 | 0.88 | MAPT (0.45) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2004616 | 0.87 | ALOX5AP (0.42) | MAPTPKMALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |