SCHEMBL2011397

SCHEMBL2011397

NC(=O)c1c(I)cc(I)c(C(=O)NCC(O)CO)c1I

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.49
CYP2C19 P33261 1/20 0.49
HIF1A Q16665 1/20 0.49
EGFR P00533 1/20 0.38
SRC P12931 1/20 0.38
CA2 P00918 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
MAP2K1 Q02750 9/20 0.36
MAP2K2 P36507 2/20 0.36
PRKCZ Q05513 1/20 0.36
IARS2 Q9NSE4 1/20 0.36
CNR2 P34972 1/20 0.32
GPR52 Q9Y2T5 1/20 0.32
ROCK2 O75116 1/20 0.32
ICAM1 P05362 1/20 0.31
LOX P28300 1/20 0.31
LOXL2 Q9Y4K0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1359643 0.93 LMNA (0.55) LMNACYP2C19HIF1AEGFRSRC
SCHEMBL5031817 0.92 LMNA (0.48) LMNACYP2C19HIF1AEGFRSRC
SCHEMBL11292903 0.88 LMNA (0.59) LMNACYP2C19HIF1AEGFRSRC
SCHEMBL8754983 0.87 LMNA (0.37) LMNACYP2C19HIF1A
SCHEMBL16875799 0.86 LMNA (0.49) LMNACYP2C19HIF1AEGFRSRC
SCHEMBL622562 0.84 LMNA (0.48) LMNACYP2C19HIF1AEGFRSRC
SCHEMBL8978121 0.84 LMNA (0.47) LMNACYP2C19HIF1AEGFRSRC
SCHEMBL30980833 0.83 LMNA (0.47) LMNACYP2C19HIF1AEGFRSRC
SCHEMBL28469692 0.82 LMNA (0.54) LMNACYP2C19HIF1AEGFRSRC
SCHEMBL29234148 0.82 LMNA (0.54) LMNACYP2C19HIF1AEGFRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113166040-B Method for preparing contrast agent iomeprol UK化学药剂有限公司 2023-10-24 CN claimed
CN-115298162-A Continuous crystallization method 通用电气医疗集团股份有限公司 2022-11-04 CN claimed
CN-113166040-A Method for preparing contrast agent iomeprol UK化学药剂有限公司 2021-07-23 CN claimed
CN-112125820-A Method for purifying contrast agent 成都西岭源药业有限公司 2020-12-25 CN claimed
WO-2020060010-A1 METHOD FOR PREPARING CONTRAST AGENT IOMEPROL (주)유케이케미팜 2020-03-26 WO claimed
US-9834504-B2 Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents GE HEALTHCARE AS (NO) 2017-12-05 US claimed
EP-2504298-B1 PREPARATION AND PURIFICATION OF IODIXANOL IMAX DIAGNOSTIC IMAGING HOLDING LTD (CN) 2016-09-21 EP claimed
US-8962886-B2 Synthesis of iodixanol in methanol GE HEALTHCARE AS (NO) 2015-02-24 US claimed
US-8766002-B2 Preparation and purification of iodixanol IMAX DIAGNOSTIC IMAGING HOLDING LIMITED (HK) 2014-07-01 US claimed
US-20120283474-A1 Preparation and Purification of Iodixanol HOVIONE CHINA HOLDING LIMITED (CN) 2012-11-08 US claimed
EP-1150943-B1 PREPARATION OF IODIXANOL AMERSHAM HEALTH AS (NO) 2003-09-10 EP claimed
EP-0839056-A4 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL INC (US) 2000-09-13 EP claimed
EP-0886634-A4 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL INC (US) 2000-08-02 EP claimed
EP-0886634-A1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL, INC. (US) 1998-12-30 EP claimed
EP-0839056-A1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL, INC. (US) 1998-05-06 EP claimed
WO-1997027172-A1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL, INC. (US) 1997-07-31 WO claimed
EP-0470247-B1 REVERSED PHASE CHROMATOGRAPHIC PROCESS MALLINCKRODT INC (US) 1997-04-16 EP claimed
WO-1996040286-A1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL, INC. (US) 1996-12-19 WO claimed
EP-0642492-A1 5,5'-/(1,3-PROPANEDIYL) BIS-/IMINO(2-OXO-2,1-ETHANEDIYL)ACETYLIMINO/BIS(2,4,6-TRIIODO-1,3-BENZENEDICARBOXYAMIDES), AND CONTRAST MEDIA CONTAINING THEM. DIBRA SPA (IT) 1995-03-15 EP claimed
CN-118239857-A Preparation method of iodixanol impurity I 浙江海洲制药股份有限公司 2024-06-25 CN disclosed
CN-118139611-A Iodine labeled hydrogels with improved radiopacity and precursors thereof 波士顿科学医学有限公司 2024-06-04 CN disclosed
CN-117658844-A New crystal form of iomeprol and preparation method thereof 成都倍特药业股份有限公司 2024-03-08 CN disclosed
CN-115611761-B Preparation method of iohexol or iodixanol and intermediate thereof 杭州新曦科技有限公司 2023-11-24 CN disclosed
CN-117083262-A Iodinated compounds with radiocontrast properties 波士顿科学国际有限公司 2023-11-17 CN disclosed
CN-113166040-B Method for preparing contrast agent iomeprol UK化学药剂有限公司 2023-10-24 CN disclosed
CN-116836076-A Preparation method of iohexol hydrolysate monohydroxy esterified impurity 江西兄弟医药有限公司 2023-10-03 CN disclosed
CN-116768747-A Intermediate of ioversol and method for preparing ioversol 江苏宇田医药有限公司 2023-09-19 CN disclosed
CN-116583304-A Polysaccharide with improved radiocontrast properties 波士顿科学医学有限公司 2023-08-11 CN disclosed
CN-116496171-A Synthesis of iohexol 上海慧聚药业有限公司 2023-07-28 CN disclosed
CN-116496171-A Synthesis of iohexol 上海慧聚药业有限公司 2023-07-28 CN disclosed
CN-112125820-B Method for purifying contrast agent 成都西岭源药业有限公司 2023-05-02 CN disclosed
CN-115611761-A Preparation method of iohexol or iodixanol and intermediate thereof 杭州新曦科技有限公司 2023-01-17 CN disclosed
CN-111440084-B Purification method of iodixanol 苏州纳微科技股份有限公司 2023-01-06 CN disclosed
CN-115298162-A Continuous crystallization method 通用电气医疗集团股份有限公司 2022-11-04 CN disclosed
CN-115298162-A Continuous crystallization method 通用电气医疗集团股份有限公司 2022-11-04 CN disclosed
CN-111943863-B Preparation method of iodixanol 江苏悦兴医药技术有限公司 2022-10-21 CN disclosed
CN-108947959-B Preparation method of non-ionic iodine contrast agent intermediate 正大天晴药业集团股份有限公司 2022-09-20 CN disclosed
CN-114716339-A Industrial preparation method of iodixanol 安徽普利药业有限公司 2022-07-08 CN disclosed
CN-114716339-A Industrial preparation method of iodixanol 安徽普利药业有限公司 2022-07-08 CN disclosed
CN-114621112-A Preparation method of iohexol intermediate 海南普利制药股份有限公司 2022-06-14 CN disclosed
CN-114269393-A Reactive multiarm polymers with branched end groups 波士顿科学医学有限公司 2022-04-01 CN disclosed
CN-114213273-A Synthesis method of iomeprol 兄弟科技股份有限公司 2022-03-22 CN disclosed
CN-114207444-A High sensitivity particle-enhanced assay for the quantification of NT-proBNP 挪威金田有限公司 2022-03-18 CN disclosed
CN-107428665-B Method for producing (meth) acrylic ester 东亚合成株式会社 2021-10-15 CN disclosed
CN-107406363-B Method for producing (meth) acrylic ester 东亚合成株式会社 2021-10-08 CN disclosed
CN-113423691-A Peptide binding agents 赛诺菲 2021-09-21 CN disclosed
CN-113395982-A Insulin conjugates 赛诺菲 2021-09-14 CN disclosed
CN-113166040-A Method for preparing contrast agent iomeprol UK化学药剂有限公司 2021-07-23 CN disclosed
CN-113166040-A Method for preparing contrast agent iomeprol UK化学药剂有限公司 2021-07-23 CN disclosed
CN-107709377-B Curable composition 东亚合成株式会社 2021-04-20 CN disclosed
CN-107698457-B Crystallization and purification method of iodixanol 正大天晴药业集团股份有限公司 2021-04-02 CN disclosed
CN-112125820-A Method for purifying contrast agent 成都西岭源药业有限公司 2020-12-25 CN disclosed
CN-111943863-A Preparation method of iodixanol 江苏悦兴医药技术有限公司 2020-11-17 CN disclosed
CN-107709376-B Curable composition 东亚合成株式会社 2020-10-30 CN disclosed
CN-107922555-B Curable composition 东亚合成株式会社 2020-08-28 CN disclosed
CN-111440084-A Purification method of iodixanol 苏州纳微科技股份有限公司 2020-07-24 CN disclosed
CN-107074549-B Separation of semiconducting and metallic single-walled carbon nanotubes using polytungstate 巴斯夫欧洲公司 2020-05-19 CN disclosed
WO-2020060010-A1 METHOD FOR PREPARING CONTRAST AGENT IOMEPROL (주)유케이케미팜 2020-03-26 WO disclosed
CN-103998349-B Contrast media packaging 通用电气医疗集团股份有限公司 2020-01-14 CN disclosed
US-10322166-B2 Composition and method for the treatment or prevention of spinal disorders KUNOVUS PTY LTD (AU) 2019-06-18 US disclosed
CN-106749323-B A kind of preparation method of Ioversol impurity 江苏恒瑞医药股份有限公司 2018-10-09 CN disclosed
EP-3313987-A1 METHOD FOR LARGE SCALE PRODUCTION AND PURIFICATION OF PARVOVIRUS Deutsches Krebsforschungszentrum (DE) 2018-05-02 EP disclosed
EP-3277299-A1 PARVOVIRUS FORMULATION FOR TREATING TUMORS Deutsches Krebsforschungszentrum (DE) 2018-02-07 EP disclosed
US-9834504-B2 Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents GE HEALTHCARE AS (NO) 2017-12-05 US disclosed
CN-106749323-A A kind of preparation method of Ioversol impurity 江苏恒瑞医药股份有限公司 2017-05-31 CN disclosed
US-20170119848-A1 COMPOSITION AND METHOD FOR THE TREATMENT OR PREVENTION OF SPINAL DISORDERS KUNOVUS PTY LTD (AU) 2017-05-04 US disclosed
WO-2016206807-A1 METHOD FOR LARGE SCALE PRODUCTION AND PURIFICATION OF PARVOVIRUS DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) 2016-12-29 WO disclosed
WO-2016206844-A1 PARVOVIRUS FORMULATION FOR TREATING TUMORS DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) 2016-12-29 WO disclosed
US-20160297749-A1 ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS GE HEALTHCARE AS (NO) 2016-10-13 US disclosed
EP-2504298-B1 PREPARATION AND PURIFICATION OF IODIXANOL IMAX DIAGNOSTIC IMAGING HOLDING LTD (CN) 2016-09-21 EP disclosed
US-8766002-B2 Preparation and purification of iodixanol IMAX DIAGNOSTIC IMAGING HOLDING LIMITED (HK) 2014-07-01 US disclosed
EP-2277854-B1 Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol GE HEALTHCARE AS (NO) 2014-06-25 EP disclosed
EP-2277853-B1 Synthesis of iodixanol in methanol GE HEALTHCARE AS (NO) 2014-06-25 EP disclosed
EP-2279998-B1 Synthesis of iodixanol in propyleneglycol GE HEALTHCARE AS (NO) 2014-06-25 EP disclosed
US-20120283474-A1 Preparation and Purification of Iodixanol HOVIONE CHINA HOLDING LIMITED (CN) 2012-11-08 US disclosed
EP-2504298-A1 PREPARATION AND PURIFICATION OF IODIXANOL Hovione China Holding Limited (CN) 2012-10-03 EP disclosed
EP-2240432-B1 PROCESS FOR THE PREPARATION OF IOSIMENOL MALLINCKRODT LLC (US) 2012-07-04 EP disclosed
WO-2011063551-A1 PREPARATION AND PURIFICATION OF IODIXANOL HOVIONE CHINA HOLDING LIMITED (CN) 2011-06-03 WO disclosed
EP-2240432-A1 PROCESS FOR THE PREPARATION OF IOSIMENOL Mallinckrodt Inc. (US) 2010-10-20 EP disclosed
EP-2229147-A2 METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES The Johns Hopkins University (US) 2010-09-22 EP disclosed
CN-101830825-A Alternative dimerisation reagents for iodixanol synthesis GE HEALTHCARE AS 2010-09-15 CN disclosed
WO-2009091758-A1 PROCESS FOR THE PREPARATION OF IOSIMENOL MALLINCKRODT INC. (US) 2009-07-23 WO disclosed
WO-2009073193-A2 METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES THE JOHNS HOPKINS UNIVERSITY (US) 2009-06-11 WO disclosed
WO-2008101300-A1 COMPOSITION AND METHOD FOR THE TREATMENT OR PREVENTION OF SPINAL DISORDERS CELLIXE PTY LTD (AU) 2008-08-28 WO disclosed
WO-2007127231-A2 MAGNETIC RESONANCE-DETECTABLE, ULTRASOUND-DETECTABLE AND/OR RADIOPAQUE MICROCAPSULES AND USES THEREOF THE JOHNS HOPKINS UNIVERSITY (US) 2007-11-08 WO disclosed
CN-1721393-A Process for preparing 5-acetamino-N,N'-bis (2,3-dihydroxypropyl)-2,4,6-tri-iodo isophthalamide XINCHANG GUOBANG CHEMICAL INDU (CN) 2006-01-18 CN disclosed
US-6596904-B1 Process for producing ioversol MALLINC KRODT INC 2003-07-22 US disclosed
EP-0839056-B1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT INC (US) 2003-05-07 EP disclosed
EP-0886634-B1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT INC (US) 2002-04-24 EP disclosed
EP-0915835-B1 A PROCESS FOR THE PREPARATION OF 5- ACETYL (2,3-DIHYDROXYPROPYL)AMINO]-N,N'-BIS (2,3-DIHYDROXYPROPYL)-2,4,6- TRIIODO-1,3-BENZENEDICARBOXAMIDE BRACCO SPA (IT) 2000-12-20 EP disclosed
EP-0839056-A4 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL INC (US) 2000-09-13 EP disclosed
EP-0886634-A4 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL INC (US) 2000-08-02 EP disclosed
EP-0941129-A1 PROCESS FOR THE PRODUCTION OF IODINATED ORGANIC X-RAY CONTRAST AGENTS NYCOMED IMAGING AS (NO) 1999-09-15 EP disclosed
EP-0923537-A1 PROCESS FOR THE PREPARATION OF CONTRAST AGENTS NYCOMED IMAGING AS (NO) 1999-06-23 EP disclosed
EP-0915835-A1 A PROCESS FOR THE PREPARATION OF 5- ACETYL (2,3-DIHYDROXYPROPYL)AMINO]-N,N'-BIS (2,3-DIHYDROXYPROPYL)-2,4,6- TRIIODO-1,3-BENZENEDICARBOXAMIDE BRACCO S.p.A. (IT) 1999-05-19 EP disclosed
EP-0886634-A1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL, INC. (US) 1998-12-30 EP disclosed
WO-1998054124-A1 A PROCESS FOR THE PREPARATION OF 5-[ACETYL (2,3-DIHYDROXYPROPYL)AMINO]-N,N'-BIS (2,3-DIHYDROXYPROPYL)-2,4,6- TRIIODO-1,3-BENZENEDICARBOXAMIDE BRACCO S.P.A. (IT) 1998-12-03 WO disclosed
WO-1998023296-A1 PROCESS FOR THE PRODUCTION OF IODINATED ORGANIC X-RAY CONTRAST AGENTS NYCOMED IMAGING AS (NO) 1998-06-04 WO disclosed
EP-0839056-A1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL, INC. (US) 1998-05-06 EP disclosed
WO-1998008805-A1 PROCESS FOR THE PREPARATION OF CONTRAST AGENTS NYCOMED IMAGING AS (NO) 1998-03-05 WO disclosed
WO-1997027172-A1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL, INC. (US) 1997-07-31 WO disclosed
US-5648536-A Process for producing ioversol LAFAYETTE PHARMACEUTICALS LLC 1997-07-15 US disclosed
EP-0762900-A4 IMPROVED SYNTHESIS OF IOVERSOL USING PHOSPHORIC ACID MODIFIED CO-ADDITION MALLINCKRODT MEDICAL INC (US) 1997-05-07 EP disclosed
EP-0762900-A1 IMPROVED SYNTHESIS OF IOVERSOL USING PHOSPHORIC ACID MODIFIED CO-ADDITION MALLINCKRODT MEDICAL, INC. (US) 1997-03-19 EP disclosed
WO-1996040286-A1 PROCESS FOR PRODUCING IOVERSOL MALLINCKRODT MEDICAL, INC. (US) 1996-12-19 WO disclosed
WO-1995035122-A1 IMPROVED SYNTHESIS OF IOVERSOL USING PHOSPHORIC ACID MODIFIED CO-ADDITION MALLINCKRODT MEDICAL, INC. (US) 1995-12-28 WO disclosed
EP-0484328-B1 PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS MALLINCKRODT INC (US) 1995-06-14 EP disclosed
EP-0619744-A4 NONIONIC X-RAY CONTRAST AGENTS, COMPOSITIONS AND METHODS. MALLINCKRODT MEDICAL INC (US) 1995-02-08 EP disclosed
EP-0619744-A1 NONIONIC X-RAY CONTRAST AGENTS, COMPOSITIONS AND METHODS MALLINCKRODT MEDICAL, INC. (US) 1994-10-19 EP disclosed
US-5322934-A Purification of a crude MRI agent using continuous deionization MALLINCKRODT MEDICAL, INC. (US) 1994-06-21 US disclosed
US-5210300-A PURIFICATION OF CRUDE IOVERSOL USING CONTINUOUS DEIONIZATION MALINCKRODT MEDICAL, INC. (US) 1993-05-11 US disclosed
US-5204005-A Decolorization, separation, purification of water-soluble nonionic contrast media compounds; removing nonionic impurities MALLINCKRODT, INC. (US) 1993-04-20 US disclosed
EP-0278674-B1 STERILIZATION OF COMPOSITIONS OF LIMITED STABILITY COOK IMAGING CORPORATION (US) 1992-08-12 EP disclosed
EP-0484328-A1 PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-N-ALKYLISOPHTHALAMIC ACID AND 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS. MALLINCKRODT INC (US) 1992-05-13 EP disclosed
WO-1991012868-A1 REVERSED PHASE CHROMATOGRAPHIC PROCESS MALLINCKRODT, INC. (US) 1991-09-05 WO disclosed
US-5013865-A X-ray contrast media, controlled stoichiometry and kinetics MALLINCKRODT, INC. (US) 1991-05-07 US disclosed
WO-1991001296-A1 PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-N-ALKYLISOPHTHALAMIC ACID AND 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS MALLINCKRODT, INC. (US) 1991-02-07 WO disclosed
US-4863714-A CARBOXYLATE BUFFER, ACIDITY, HEAT TREATMENT COOK IMAGING CORPORATION (US) 1989-09-05 US disclosed
US-4863714-A CARBOXYLATE BUFFER, ACIDITY, HEAT TREATMENT COOK IMAGING CORPORATION (US) 1989-09-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160297749-A1 ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS NISCH, PPIP5K2, IPO4 LMNA 2318/4885CYP2C19 3110/4885HIF1A 1983/4885
US-20120283474-A1 Preparation and Purification of Iodixanol INSRR, DBH, IGF2R LMNA 1761/4885CYP2C19 1568/4885HIF1A 1036/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.