SCHEMBL20114083

SCHEMBL20114083

C=C(Cc1ccc(Br)cc1-c1ccccc1C)c1cccc(-c2ccccc2)c1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.38
FFAR1 O14842 1/20 0.38
HDAC8 Q9BY41 1/20 0.34
ALDH1A1 P00352 1/20 0.34
PTGER1 P34995 2/20 0.34
KMO O15229 1/20 0.33
SLC6A9 P48067 1/20 0.33
PRSS1 P07477 1/20 0.33
PRSS2 P07478 1/20 0.33
PRSS3 P35030 1/20 0.33
SENP1 Q9P0U3 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
ERCC5 P28715 1/20 0.32
FEN1 P39748 1/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
SMYD2 Q9NRG4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20114097 0.76 HTR7 (0.42) FFAR1ALDH1A1SLC6A9
SCHEMBL24651175 0.75 NPC1 (0.40) FFAR1ALDH1A1
SCHEMBL20114041 0.73 ALDH1A1 (0.38) FFAR1ALDH1A1SLC6A9
SCHEMBL20114168 0.71 ALOX5 (0.41) HDAC8ALDH1A1
SCHEMBL20114078 0.71 ALDH1A1 (0.40) NR1H4ALDH1A1SLC6A9
SCHEMBL20114138 0.69 ALDH1A1 (0.36) ALDH1A1
SCHEMBL38664634 0.68 KMO (0.48) NR1H4HDAC8KMOPRSS1PRSS2
SCHEMBL28165717 0.68 DPP4 (0.42) ALDH1A1PDCD1CD274
SCHEMBL26828809 0.68 PRSS1 (0.49) NR1H4HDAC8ALDH1A1KMOPRSS1
SCHEMBL26828815 0.67 PRSS1 (0.47) HDAC8ALDH1A1KMOPRSS1PRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018080067-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE INCLUDING SAME 주식회사 두산 2018-05-03 WO disclosed