Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067940 | 0.77 | RXRA (0.43) | KDM4EHPGDHSD17B10ALDH1A1NFKB1 | |
| SCHEMBL17316510 | 0.73 | PGR (0.48) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL304685 | 0.70 | CA1 (0.38) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL560834 | 0.69 | CA1 (0.38) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL23724053 | 0.68 | CYP26B1 (0.34) | ALDH1A1GAATDP1CYP26B1 | |
| SCHEMBL6148042 | 0.67 | CYP26A1 (0.71) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL6144438 | 0.67 | CYP26A1 (0.58) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL30019816 | 0.67 | PDK2 (0.46) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL20975416 | 0.67 | PDK2 (0.46) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL5670401 | 0.66 | ALDH1A1 (0.39) | KDM4EHPGDHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9248203-B2 | Fluorescent imaging with substituted cyanine dyes | LI-COR, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-9089603-B2 | Fluorescent imaging with substituted cyanine dyes | LI-COR, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-20130280172-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | MIDCAP FINANCIAL TRUST | 2013-10-24 | — | — | US | disclosed |
| US-20130039860-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | LI-COR, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20120183949-A1 | Method, device, or system using lung sensor for detecting a physiological condition in a vertebrate subject | SEARETE LLC, A LIMITED LIABILITY CORPORATION OF THE STATE OF DELAWARE | 2012-07-19 | — | — | US | disclosed |
| WO-2012054784-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | LI-COR, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| US-7964361-B2 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2011-06-21 | — | — | US | disclosed |
| US-20090281279-A1 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
| US-7408062-B2 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2008-08-05 | — | — | US | disclosed |
| US-20070243527-A9 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE MELLON UNIVERSITY | 2007-10-18 | — | — | US | disclosed |
| US-6686145-B1 | IMPARTING FLUORESCENT PROPERTIES TO TARGET MATERIALS BY COVALENT AND NONCOVALENT ASSOCIATION | CARNEGIE MELLON UNIVERSITY | 2004-02-03 | — | — | US | disclosed |
| US-20030224391-A1 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY | 2003-12-04 | — | — | US | disclosed |
| EP-1042407-B1 | RIGIDIZED TRIMETHINE CYANINE DYES | UNIV CARNEGIE MELLON (US) | 2001-09-12 | — | — | EP | disclosed |
| US-6133445-A | USEFUL FOR IMPARTING FLUORESCENT PROPERTIES TO TARGET MATERIALS | CARNEGIE MELLON UNIVERSITY (US) | 2000-10-17 | — | — | US | disclosed |
| EP-1042407-A1 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE-MELLON UNIVERSITY (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031181-A1 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE MELLON UNIVERSITY (US) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070243527-A9 | RIGIDIZED TRIMETHINE CYANINE DYES | SIGMAR1, CBR1, NR0B1 | KDM4E 771/4885HPGD 4302/4885HSD17B10 724/4885 |
| US-20090281279-A1 | Rigidized trimethine cyanine dyes | CD47, TLN1, TPM4 | KDM4E 174/4885HPGD 4535/4885HSD17B10 4520/4885 |
| US-20030224391-A1 | Rigidized trimethine cyanine dyes | CBR1, TH, CBR3 | KDM4E 408/4885HPGD 4367/4885HSD17B10 2451/4885 |
| US-20130280172-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | TIE1, ALG1, MSR1 | KDM4E 2199/4885HPGD 1834/4885HSD17B10 3351/4885 |
| US-20130039860-A1 | FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES | TIE1, ALG1, MSR1 | KDM4E 2199/4885HPGD 1834/4885HSD17B10 3351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.