Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013294 | 0.78 | KMT2A (0.55) | L3MBTL1ALDH1A1TDP1HPGDNPC1 | |
| SCHEMBL12572189 | 0.77 | S100A4 (0.40) | ALDH1A1LMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL1890141 | 0.77 | S100A4 (0.40) | ALDH1A1LMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL2011606 | 0.77 | P2RX3 (0.37) | L3MBTL1ALDH1A1TDP1HPGDMAPK1 | |
| SCHEMBL17506413 | 0.75 | HTR6 (0.54) | L3MBTL1ALDH1A1TDP1HPGDNPC1 | |
| SCHEMBL30026729 | 0.75 | HTR6 (0.54) | L3MBTL1ALDH1A1TDP1HPGDNPC1 | |
| SCHEMBL2011752 | 0.74 | NPC1 (0.42) | L3MBTL1ALDH1A1TDP1HPGDNPC1 | |
| SCHEMBL27839175 | 0.74 | PDK1 (0.44) | ALDH1A1RAB9AMAPK1LMNAMEN1 | |
| SCHEMBL4440523 | 0.73 | P2RX3 (0.42) | ALDH1A1LMNAGAAKMT2ACYP1A2 | |
| SCHEMBL29509060 | 0.73 | PDK1 (0.47) | L3MBTL1ALDH1A1TDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |