Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739618 | 0.84 | L3MBTL1 (0.61) | KMT2AL3MBTL1POLBMEN1MAPT | |
| SCHEMBL10171014 | 0.79 | TDP1 (0.48) | KMT2APOLBMEN1MAPTALDH1A1 | |
| SCHEMBL2011750 | 0.78 | L3MBTL1 (0.43) | KMT2AL3MBTL1POLBMEN1MAPT | |
| SCHEMBL8075197 | 0.77 | HPSE (0.55) | KMT2AL3MBTL1POLBMEN1MAPT | |
| SCHEMBL1367387 | 0.77 | L3MBTL1 (0.52) | KMT2AL3MBTL1POLBMEN1MAPT | |
| SCHEMBL8077126 | 0.77 | MAPT (0.48) | KMT2AL3MBTL1POLBMEN1MAPT | |
| SCHEMBL1890689 | 0.77 | MAPT (0.51) | KMT2AMEN1MAPTF10RAB9A | |
| SCHEMBL9658168 | 0.76 | ALDH1A1 (0.51) | KMT2AL3MBTL1POLBMEN1MAPT | |
| SCHEMBL9853813 | 0.76 | KMT2A (0.49) | KMT2AL3MBTL1POLBMEN1MAPT | |
| SCHEMBL25294499 | 0.76 | CFD (0.43) | KMT2APOLBMEN1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |