Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011930 | 0.87 | HTR1A (0.43) | HTR1ADRD2KDM4ELMNACHRM2 | |
| Hydrochloric Acid SCHEMBL2012931 | 0.86 | HTR1A (0.42) | HTR1ADRD2KDM4ELMNACHRM2 | |
| SCHEMBL3841214 | 0.75 | TDP1 (0.51) | HTR1ADRD2KDM4ELMNACHRM2 | |
| SCHEMBL7292776 | 0.75 | HTR1A (0.46) | HTR1ADRD2KDM4ELMNACHRM2 | |
| SCHEMBL2011929 | 0.75 | HTR1A (0.44) | HTR1ADRD2KDM4ELMNACHRM2 | |
| SCHEMBL2011768 | 0.74 | DRD2 (0.43) | HTR1ADRD2KDM4ELMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL2012002 | 0.74 | TDP1 (0.50) | HTR1ADRD2KDM4ELMNACHRM2 | |
| SCHEMBL10867623 | 0.74 | HTR1A (0.45) | HTR1ADRD2KDM4ELMNACHRM2 | |
| Hydrochloric Acid SCHEMBL2012929 | 0.74 | HTR1A (0.43) | HTR1ADRD2KDM4ELMNACHRM2 | |
| SCHEMBL13618631 | 0.73 | HTR1A (0.43) | HTR1ADRD2KDM4ELMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513055-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | Pharmathen S.A. (GR) | 2012-10-24 | — | — | EP | claimed |
| US-20120253051-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PHARMATHEN S.A. (GR) | 2012-10-04 | — | — | US | claimed |
| WO-2011072704-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PHARMATHEN S.A. (GR) | 2011-06-23 | — | — | WO | claimed |
| US-7619095-B2 | Process for the preparation of indolone derivative | ALEMBIC LIMITED (IN) | 2009-11-17 | — | — | US | claimed |
| EP-1848691-B1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LTD (IN) | 2009-11-11 | — | — | EP | claimed |
| US-20080262244-A1 | Process for the Preparation of Indolone Derivative | ALEMBIC LIMITED (IN) | 2008-10-23 | — | — | US | claimed |
| EP-1848691-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | Alembic Limited (IN) | 2007-10-31 | — | — | EP | claimed |
| WO-2006123356-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LIMITED (IN) | 2006-11-23 | — | — | WO | claimed |
| CN-116262706-A | Preparation process of ropinirole intermediate | 浙江华海药业股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-116262706-A | Preparation process of ropinirole intermediate | 浙江华海药业股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| EP-2513055-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | Pharmathen S.A. (GR) | 2012-10-24 | — | — | EP | disclosed |
| US-20120253051-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PHARMATHEN S.A. (GR) | 2012-10-04 | — | — | US | disclosed |
| WO-2011072704-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PHARMATHEN S.A. (GR) | 2011-06-23 | — | — | WO | disclosed |
| US-7619095-B2 | Process for the preparation of indolone derivative | ALEMBIC LIMITED (IN) | 2009-11-17 | — | — | US | disclosed |
| EP-1848691-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | Alembic Limited (IN) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006123356-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LIMITED (IN) | 2006-11-23 | — | — | WO | disclosed |
| EP-0113964-B1 | 4-AMINOALKYL-2(3H)-INDOLONES | SMITHKLINE BECKMAN CORPORATION (US) | 1986-10-22 | — | — | EP | disclosed |
| US-4588740-A | Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones | SMITHKLINE BECKMAN CORPORATION (US) | 1986-05-13 | — | — | US | disclosed |
| EP-0113964-A1 | 4-Aminoalkyl-2(3H)-indolones | SMITHKLINE BECKMAN CORPORATION (US) | 1984-07-25 | — | — | EP | disclosed |
| US-4452808-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262244-A1 | Process for the Preparation of Indolone Derivative | HTR3C, HTR3B, HTR1B | HTR1A 16/4885DRD2 48/4885KDM4E 627/4885 |
| US-20120253051-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PRLHR, ADCYAP1R1, REN | HTR1A 792/4885DRD2 26/4885KDM4E 2013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.