Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623334 | 0.86 | HTR1A (0.43) | DRD2HTR1AACHEBCHEKMT2A | |
| SCHEMBL13618631 | 0.86 | HTR1A (0.43) | DRD2HTR1AACHEBCHEKMT2A | |
| SCHEMBL2011929 | 0.86 | HTR1A (0.44) | DRD2HTR1AACHEBCHEKMT2A | |
| Hydrochloric Acid SCHEMBL2012929 | 0.85 | HTR1A (0.43) | DRD2HTR1AACHEBCHEKMT2A | |
| SCHEMBL1716245 | 0.82 | CES2 (0.46) | ACHECES2CES1CACNA1CMAPT | |
| SCHEMBL13930332 | 0.78 | L3MBTL1 (0.48) | ACHECES2CES1CACNA1CMAPT | |
| SCHEMBL31016530 | 0.78 | L3MBTL1 (0.48) | ACHECES2CES1CACNA1CMAPT | |
| SCHEMBL3841214 | 0.77 | TDP1 (0.51) | DRD2HTR1AKMT2AKDM4ESIGMAR1 | |
| SCHEMBL13930337 | 0.76 | ALDH1A1 (0.51) | DRD2HTR1AACHEBCHEMAPT | |
| SCHEMBL16585208 | 0.76 | LMNA (0.44) | ACHECES2CES1CACNA1CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513055-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | Pharmathen S.A. (GR) | 2012-10-24 | — | — | EP | claimed |
| WO-2011072704-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PHARMATHEN S.A. (GR) | 2011-06-23 | — | — | WO | claimed |
| CN-116262706-A | Preparation process of ropinirole intermediate | 浙江华海药业股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-116262706-A | Preparation process of ropinirole intermediate | 浙江华海药业股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| EP-2513055-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | Pharmathen S.A. (GR) | 2012-10-24 | — | — | EP | disclosed |
| US-20120253051-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PHARMATHEN S.A. (GR) | 2012-10-04 | — | — | US | disclosed |
| US-20120253051-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PHARMATHEN S.A. (GR) | 2012-10-04 | — | — | US | disclosed |
| WO-2011072704-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PHARMATHEN S.A. (GR) | 2011-06-23 | — | — | WO | disclosed |
| US-7619095-B2 | Process for the preparation of indolone derivative | ALEMBIC LIMITED (IN) | 2009-11-17 | — | — | US | disclosed |
| US-7619095-B2 | Process for the preparation of indolone derivative | ALEMBIC LIMITED (IN) | 2009-11-17 | — | — | US | disclosed |
| EP-1848691-B1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LTD (IN) | 2009-11-11 | — | — | EP | disclosed |
| US-20080262244-A1 | Process for the Preparation of Indolone Derivative | ALEMBIC LIMITED (IN) | 2008-10-23 | — | — | US | disclosed |
| US-20080262244-A1 | Process for the Preparation of Indolone Derivative | ALEMBIC LIMITED (IN) | 2008-10-23 | — | — | US | disclosed |
| WO-2006123356-A1 | PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE | ALEMBIC LIMITED (IN) | 2006-11-23 | — | — | WO | disclosed |
| EP-0113964-B1 | 4-AMINOALKYL-2(3H)-INDOLONES | SMITHKLINE BECKMAN CORPORATION (US) | 1986-10-22 | — | — | EP | disclosed |
| US-4588740-A | Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones | SMITHKLINE BECKMAN CORPORATION (US) | 1986-05-13 | — | — | US | disclosed |
| EP-0113964-A1 | 4-Aminoalkyl-2(3H)-indolones | SMITHKLINE BECKMAN CORPORATION (US) | 1984-07-25 | — | — | EP | disclosed |
| US-4452808-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262244-A1 | Process for the Preparation of Indolone Derivative | HTR3C, HTR3B, HTR1B | DRD2 48/4885HTR1A 16/4885ACHE 691/4885 |
| US-20120253051-A1 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF | PRLHR, ADCYAP1R1, REN | DRD2 26/4885HTR1A 792/4885ACHE 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.