Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 2/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CD38 | P28907 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118191 | 0.87 | CRHR1 (0.43) | TNKSCRHR1CRHR2HPGDMEN1 | |
| SCHEMBL20118412 | 0.83 | TNKS (0.43) | TNKSCRHR1CRHR2HPGDMEN1 | |
| SCHEMBL20118132 | 0.81 | LMNA (0.46) | TNKSCRHR1CRHR2HPGDPDE4B | |
| SCHEMBL20118038 | 0.81 | CRHR1 (0.41) | CRHR1CRHR2HPGDMEN1KMT2A | |
| SCHEMBL20118418 | 0.81 | CRHR1 (0.40) | CRHR1CRHR2PDE4B | |
| SCHEMBL20118117 | 0.80 | KMT2A (0.41) | CRHR1CRHR2HPGDMEN1KMT2A | |
| SCHEMBL20118070 | 0.80 | CRHR1 (0.42) | CRHR1CRHR2HPGDKMT2APDE4B | |
| SCHEMBL20118174 | 0.79 | CRHR1 (0.40) | CRHR1CRHR2HPGDMEN1KMT2A | |
| SCHEMBL20118108 | 0.79 | PSEN1 (0.35) | CRHR1CRHR2MEN1KMT2A | |
| SCHEMBL20118068 | 0.78 | CRHR1 (0.39) | CRHR1CRHR2HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |