Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118184 | 0.84 | CRHR1 (0.39) | CRHR1CRHR2MEN1KMT2APDE4B | |
| SCHEMBL20118407 | 0.84 | PDE4B (0.40) | CRHR1CRHR2PDE4B | |
| SCHEMBL20118406 | 0.82 | DHODH (0.44) | GRM5MEN1KMT2APDE4BSMYD3 | |
| SCHEMBL20118187 | 0.82 | PDE4B (0.41) | CRHR1CRHR2PDE4BHPGD | |
| SCHEMBL20118213 | 0.82 | LMNA (0.42) | CRHR1CRHR2PDE4BHPGD | |
| SCHEMBL20118188 | 0.80 | KDM4E (0.47) | — | |
| SCHEMBL20118191 | 0.79 | CRHR1 (0.43) | CRHR1CRHR2MEN1KMT2APDE4B | |
| SCHEMBL20118169 | 0.79 | P2RX7 (0.35) | CRHR1CRHR2 | |
| SCHEMBL20118172 | 0.79 | P2RX7 (0.35) | CRHR1CRHR2 | |
| SCHEMBL20118047 | 0.79 | RORC (0.43) | CRHR1CRHR2MEN1KMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |