Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 8/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118195 | 0.83 | HSD11B1 (0.44) | PDE4BPDE4DPDE4CNTRK1HSD11B1 | |
| SCHEMBL18208641 | 0.83 | NTRK1 (0.41) | CRHR1CRHR2PDE4BPDE4DPDE4C | |
| SCHEMBL18208638 | 0.83 | NTRK1 (0.41) | CRHR1CRHR2PDE4BPDE4DPDE4C | |
| SCHEMBL20118191 | 0.81 | CRHR1 (0.43) | CRHR1CRHR2PDE4B | |
| SCHEMBL18208727 | 0.81 | NTRK1 (0.42) | CRHR1CRHR2PDE4BPDE4DPDE4C | |
| SCHEMBL18208726 | 0.81 | NTRK1 (0.42) | CRHR1CRHR2PDE4BPDE4DPDE4C | |
| SCHEMBL20118047 | 0.81 | RORC (0.43) | CRHR1CRHR2PDE4B | |
| SCHEMBL20118132 | 0.81 | LMNA (0.46) | CRHR1CRHR2PDE4B | |
| SCHEMBL20118070 | 0.79 | CRHR1 (0.42) | CRHR1CRHR2PDE4B | |
| SCHEMBL20118235 | 0.78 | ALDH1A1 (0.53) | CRHR1CRHR2PDE4BPDE4DHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |