Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | LPL | P06858 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15799383 | 0.85 | PDE3B (0.46) | PDE3BPDE3APGRALDH1A1PKM | |
| SCHEMBL30858208 | 0.76 | CMA1 (0.47) | PDE3BPDE3APRMT5WDR77CMA1 | |
| SCHEMBL20112973 | 0.71 | PRMT5 (0.37) | PRMT5WDR77LPLLIPG | |
| SCHEMBL28391117 | 0.70 | LIPG (0.50) | LPLLIPG | |
| SCHEMBL20289678 | 0.64 | LPL (0.34) | LPLLIPG | |
| SCHEMBL20106736 | 0.64 | GRIA1 (0.34) | GRIA1 | |
| SCHEMBL1226551 | 0.64 | LPL (0.42) | PDE3BPDE3APRMT5WDR77PKM | |
| SCHEMBL19411660 | 0.64 | PIK3CD (0.38) | PGRPRMT5WDR77BACE1LPL | |
| SCHEMBL1519980 | 0.62 | NOS1 (0.54) | PDE3BPDE3AALDH1A1LPLLIPG | |
| SCHEMBL22191290 | 0.62 | PGR (0.50) | PGRPRMT5WDR77BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018080918-A1 | 3-ARYL-2H-PYRAZOLO[4,3-B]PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |