SCHEMBL201278

SCHEMBL201278

O=C(O)c1cc(O)ccc1Cl

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.65
TP53 P04637 1/20 0.65
CA1 P00915 4/20 0.61
CA2 P00918 4/20 0.61
CA12 O43570 3/20 0.61
CA7 P43166 3/20 0.61
CA9 Q16790 3/20 0.61
CA14 Q9ULX7 3/20 0.61
ALOX5 P09917 1/20 0.61
PTGS2 P35354 1/20 0.61
TSHR P16473 2/20 0.56
TDP1 Q9NUW8 3/20 0.55
KDM4E B2RXH2 2/20 0.55
POLB P06746 2/20 0.55
NPC1 O15118 1/20 0.55
MAPT P10636 1/20 0.55
RAB9A P51151 1/20 0.55
HSD17B10 Q99714 2/20 0.53
LMNA P02545 1/20 0.53
CTSB P07858 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30442360 1.00 ALDH1A1 (0.65) ALDH1A1TP53CA1CA2CA12
Hydrochloric Acid SCHEMBL18861044 0.98 ALDH1A1 (0.63) ALDH1A1TP53CA1CA2CA12
SCHEMBL17142429 0.82 HSD17B10 (0.52) ALDH1A1TP53CA1CA2CA12
SCHEMBL945711 0.82 TSHR (0.65) ALDH1A1TP53CA1CA2CA12
SCHEMBL29567497 0.82 TSHR (0.65) ALDH1A1TP53CA1CA2CA12
Water SCHEMBL694945 0.80 TSHR (0.63) ALDH1A1TP53CA1CA2CA12
SCHEMBL201968 0.80 ALDH1A1 (0.51) ALDH1A1TP53CA1CA2CA12
SCHEMBL7306944 0.80 HSD17B10 (0.50) ALDH1A1TP53CA1CA2CA12
SCHEMBL31196555 0.80 ALDH1A1 (0.51) ALDH1A1TP53CA1CA2CA12
SCHEMBL2771204 0.79 ALDH1A1 (0.68) ALDH1A1TP53TSHRTDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112876463-B Intermediate for preparing PD-L1 antagonist and preparation method thereof 厦门宝太生物科技股份有限公司 2022-11-11 CN claimed
CN-112876463-A Intermediate for preparing PD-L1 antagonist and preparation method thereof 杭州阿诺生物医药科技有限公司 2021-06-01 CN claimed
CN-103923765-A Detergent Composition For Process Of Manufacturing Semiconductors And Displays COWON INNOTECH INC 2014-07-16 CN claimed
US-12595239-B2 Substituted isoxazoline derivatives BASF SE (DE) 2026-04-07 US disclosed
US-12583839-B2 PD-L1 antagonist compound ADLAI NORTYE BIOPHARMA CO., LTD. (CN) 2026-03-24 US disclosed
EP-4291551-B1 SUBSTITUTED ISOXAZOLINE DERIVATIVES BASF SE (DE) 2025-08-13 EP disclosed
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2025-07-03 US disclosed
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-20250170100-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF ANXIETY AND RELATED CONDITIONS PSY THERAPEUTICS, INC. (US) 2025-05-29 US disclosed
US-20250170101-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT AND MANAGEMENT OF PAIN AND RELATED CONDITIONS PSY THERAPEUTICS, INC. (US) 2025-05-29 US disclosed
US-12286421-B2 Inhibiting monoacylglycerol lipase (MAGL) PSY THERAPEUTICS, INC. (US) 2025-04-29 US disclosed
EP-0906273-A1 PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS NEUROSEARCH A/S (DK) 1999-04-07 EP disclosed
WO-1997045400-A1 PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS NEUROSEARCH A/S (DK) 1997-12-04 WO disclosed
US-4778914-A FOR HALOGENATED DIPHENYL ETHER HERBICIDE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-10-18 US disclosed
EP-0034402-B1 METHOD OF PREPARING FLUORINE-SUBSTITUTED DIPHENYL ETHER DERIVATIVES AND FLUORINE-SUBSTITUTED HALOGENO BENZENE DERIVATIVES FOR USE THEREIN IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-08-29 EP disclosed
US-4388472-A Substituted diphenyl ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-06-14 US disclosed
US-4384135-A REACTING A SUBSTITUTED BENZOTRIFLUORIDE WITH A SUBSTITUTED PHENOL IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-05-17 US disclosed
EP-0023100-B1 HERBICIDAL COMPOSITIONS COMPRISING A DIPHENYL ETHER COMPOUND IN ADMIXTURE WITH ANOTHER HERBICIDE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-10 EP disclosed
EP-0034402-A2 Method of preparing fluorine-substituted diphenyl ether derivatives and fluorine-substituted halogeno benzene derivatives for use therein IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-08-26 EP disclosed
EP-0023100-A1 Herbicidal compositions comprising a diphenyl ether compound in admixture with another herbicide IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-01-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12595239-B2 Substituted isoxazoline derivatives CBR3, ADRA2C, CYP4Z1 ALDH1A1 854/4885TP53 4755/4885CA1 2085/4885
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) MGLL, PNLIP, LIPC ALDH1A1 1923/4885TP53 4322/4885CA1 4636/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 ALDH1A1 800/4885TP53 4103/4885CA1 3391/4885
US-12286421-B2 Inhibiting monoacylglycerol lipase (MAGL) MGLL, PNLIP, LIPC ALDH1A1 1923/4885TP53 4322/4885CA1 4636/4885
US-20250170101-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT AND MANAGEMENT OF PAIN AND RELATED CONDITIONS MGLL, PNLIP, LIPA ALDH1A1 1116/4885TP53 3497/4885CA1 4618/4885
US-20250170100-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF ANXIETY AND RELATED CONDITIONS MGLL, PNLIP, LIPA ALDH1A1 1075/4885TP53 4869/4885CA1 2506/4885
US-12583839-B2 PD-L1 antagonist compound CD274, PDCD1LG2, PDCD1 ALDH1A1 747/4885TP53 927/4885CA1 1594/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.