Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | NQO1 | P15559 | 3/20 | 0.33 |
| ▸ | THRA | P10827 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10891430 | 0.79 | CYP2C9 (0.46) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL12620456 | 0.75 | CYP2C19 (0.47) | CYP2C9HSD17B10LMNAALDH1A1TYR | |
| SCHEMBL9007185 | 0.73 | LMNA (0.48) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL11087884 | 0.73 | THRA (0.44) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL8518795 | 0.72 | CYP2C9 (0.40) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL27861556 | 0.71 | ALOX15 (0.43) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL11685439 | 0.68 | ALDH1A1 (0.42) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL68860 | 0.68 | CYP2C9 (0.48) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL8655702 | 0.68 | NQO2 (0.55) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL27745048 | 0.67 | HTT (0.43) | CYP2C9HSD17B10LMNANR1I2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127396-A1 | INHIBITORS OF RAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127396-A1 | INHIBITORS OF RAS AND METHODS OF USE THEREOF | KRAS, NRAS, HRAS | CYP2C9 3239/4885HSD17B10 4683/4885LMNA 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.