Sugi Predict

Sugi Predict / Compounds / SCHEMBL20134817

SCHEMBL20134817

SCHEMBL20134817

Cc1cc(C)c(N2CCN(C(=O)c3ccc(C4(C(C)C)NC(=O)NC4=O)cc3)CC2)nc1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.37
▸ ADAMTS5 Q9UNA0 7/20 0.36
▸ ADAM17 P78536 3/20 0.36
▸ CRBN Q96SW2 2/20 0.36
▸ CYP2C9 P11712 2/20 0.36
▸ CYP2C19 P33261 2/20 0.36
▸ SMN1; SMN2 Q16637 3/20 0.35
▸ HTT P42858 3/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ NPSR1 Q6W5P4 2/20 0.35
▸ HIF1A Q16665 1/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ TSHR P16473 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ MMP1 P03956 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ CASP1 P29466 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29688621 1.00 ALDH1A1 (0.37) ALDH1A1ADAMTS5ADAM17CRBNCYP2C9
SCHEMBL20134983 0.89 ADAMTS5 (0.37) ALDH1A1ADAMTS5ADAM17CRBNSMN1; SMN2
SCHEMBL29688815 0.89 ADAMTS5 (0.37) ALDH1A1ADAMTS5ADAM17CRBNSMN1; SMN2
SCHEMBL20135075 0.87 HTT (0.40) ADAMTS5ADAM17HTTKDM4ELMNA
SCHEMBL29688993 0.87 HTT (0.40) ADAMTS5ADAM17HTTKDM4ELMNA
SCHEMBL20134796 0.86 ALDH1A1 (0.39) ALDH1A1ADAMTS5ADAM17CRBNSMN1; SMN2
SCHEMBL29688482 0.86 ALDH1A1 (0.39) ALDH1A1ADAMTS5ADAM17CRBNSMN1; SMN2
SCHEMBL20134799 0.86 ALDH1A1 (0.39) ALDH1A1ADAMTS5ADAM17CRBNSMN1; SMN2
SCHEMBL20134989 0.86 ALDH1A1 (0.40) ALDH1A1ADAMTS5ADAM17CRBNCYP2C9
SCHEMBL20134972 0.86 ALDH1A1 (0.40) ALDH1A1ADAMTS5ADAM17CRBNCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922347-B Novel imide derivatives and their use as pharmaceuticals 田边三菱制药株式会社 2022-06-28 — — CN disclosed
US-10407408-B2 Imide derivatives and use thereof as medicine MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-09-10 — — US disclosed
US-10407408-B2 Imide derivatives and use thereof as medicine MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-09-10 — — US disclosed
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-03-14 — — US disclosed
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-03-14 — — US disclosed
EP-3321256-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2018-05-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP1 ALDH1A1 584/4885ADAMTS5 23/4885ADAM17 36/4885
US-10407408-B2 Imide derivatives and use thereof as medicine MMP9, MMP2, MMP1 ALDH1A1 610/4885ADAMTS5 25/4885ADAM17 39/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.