SCHEMBL20134908

SCHEMBL20134908

C[C@]1(c2ccc(C(=O)N3CCN(c4ncc(C5CC5)cc4C4CC4)CC3)cc2)NC(=O)NC1=O

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC6A7 Q99884 1/20 0.38
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
EGLN1 Q9GZT9 4/20 0.35
CRBN Q96SW2 3/20 0.35
MGLL Q99685 1/20 0.35
NTSR1 P30989 1/20 0.35
ADAM17 P78536 1/20 0.34
KDM4E B2RXH2 2/20 0.34
LMNA P02545 1/20 0.34
RECQL P46063 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CCNK O75909 1/20 0.34
CDK12 Q9NYV4 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29688222 1.00 SLC6A7 (0.38) SLC6A7MEN1KMT2AEGLN1CRBN
SCHEMBL20134917 1.00 SLC6A7 (0.38) SLC6A7MEN1KMT2AEGLN1CRBN
SCHEMBL20134934 0.91 SLC6A7 (0.38) SLC6A7MEN1KMT2AEGLN1CRBN
SCHEMBL20134930 0.91 SLC6A7 (0.38) SLC6A7MEN1KMT2AEGLN1CRBN
SCHEMBL29688646 0.90 FASN (0.36) ADAM17KDM4ELMNAALDH1A1
SCHEMBL20135427 0.90 FASN (0.36) ADAM17KDM4ELMNAALDH1A1
SCHEMBL20135083 0.88 ADAM17 (0.41) SLC6A7EGLN1ADAM17
SCHEMBL20135712 0.88 ADAM17 (0.41) SLC6A7EGLN1ADAM17
SCHEMBL29688912 0.88 ADAM17 (0.41) SLC6A7EGLN1ADAM17
SCHEMBL29688599 0.88 ADAM17 (0.41) SLC6A7EGLN1ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10407408-B2 Imide derivatives and use thereof as medicine MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-09-10 US disclosed
US-10407408-B2 Imide derivatives and use thereof as medicine MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-09-10 US disclosed
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-03-14 US disclosed
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-03-14 US disclosed
EP-3321256-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2018-05-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP1 SLC6A7 3698/4885MEN1 3735/4885KMT2A 2568/4885
US-10407408-B2 Imide derivatives and use thereof as medicine MMP9, MMP2, MMP1 SLC6A7 3473/4885MEN1 2913/4885KMT2A 2539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.