Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014289 | 1.00 | KDM4E (0.36) | KDM4EL3MBTL1MPISLC40A1KCNMA1 | |
| SCHEMBL2011479 | 0.88 | METAP2 (0.43) | KDM4EL3MBTL1MPISLC40A1CNR2 | |
| SCHEMBL2011476 | 0.88 | METAP2 (0.43) | KDM4EL3MBTL1MPISLC40A1CNR2 | |
| SCHEMBL2018360 | 0.85 | SLC40A1 (0.36) | KDM4EL3MBTL1MPISLC40A1KCNMA1 | |
| SCHEMBL2014591 | 0.82 | METAP2 (0.44) | KDM4EL3MBTL1MPISLC40A1KCNMA1 | |
| SCHEMBL2014589 | 0.82 | METAP2 (0.44) | KDM4EL3MBTL1MPISLC40A1KCNMA1 | |
| SCHEMBL2013539 | 0.81 | LMNA (0.33) | L3MBTL1SLC40A1KCNMA1MEN1ALDH1A1 | |
| SCHEMBL2013535 | 0.81 | LMNA (0.33) | L3MBTL1SLC40A1KCNMA1MEN1ALDH1A1 | |
| SCHEMBL2014288 | 0.80 | L3MBTL1 (0.41) | KDM4EL3MBTL1MPISLC40A1KCNMA1 | |
| SCHEMBL2018094 | 0.80 | HTR1A (0.43) | KDM4EL3MBTL1HTR1AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |