Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013539 | 0.85 | LMNA (0.33) | LMNAALDH1A1HTTMAPK1SMN1; SMN2 | |
| SCHEMBL2013535 | 0.85 | LMNA (0.33) | LMNAALDH1A1HTTMAPK1SMN1; SMN2 | |
| SCHEMBL2016538 | 0.82 | PIK3CD (0.38) | HTR1ALMNAALDH1A1KDM4EGLA | |
| SCHEMBL2018094 | 0.81 | HTR1A (0.43) | HTR1ALMNAALDH1A1KDM4EGLA | |
| SCHEMBL2017050 | 0.79 | SLC40A1 (0.40) | LMNAALDH1A1KDM4ENPSR1HTT | |
| SCHEMBL2013366 | 0.78 | CCR4 (0.37) | LMNAALDH1A1NPSR1HTTMAPK1 | |
| SCHEMBL2016811 | 0.77 | METAP2 (0.34) | LMNAALDH1A1KDM4ENPSR1HTT | |
| SCHEMBL2051951 | 0.76 | PIK3CD (0.35) | LMNAALDH1A1KDM4ENPSR1HTT | |
| SCHEMBL2012932 | 0.76 | ABCC1 (0.33) | LMNAALDH1A1KDM4ENPSR1HTT | |
| SCHEMBL2013837 | 0.76 | BTK (0.37) | LMNAALDH1A1KDM4ENPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |