SCHEMBL201354

SCHEMBL201354

Clc1ccc(-c2coc(COCc3ccccc3)n2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 4/20 0.51
ADRB1 P08588 1/20 0.48
ADRB3 P13945 1/20 0.48
ENPP3 O14638 1/20 0.47
ENPP1 P22413 1/20 0.47
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
HPGD P15428 2/20 0.43
NPSR1 Q6W5P4 1/20 0.43
LTA4H P09960 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
RAB9A P51151 3/20 0.42
NPC1 O15118 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TSHR P16473 2/20 0.42
PTGER1 P34995 1/20 0.40
DHFR P00374 1/20 0.40
GHSR Q92847 1/20 0.40
TP53 P04637 1/20 0.40
MAPK1 P28482 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18581467 0.90 ADRB1 (0.49) DHODHADRB1ADRB3ENPP3ENPP1
SCHEMBL2707290 0.86 ENPP3 (0.53) DHODHADRB1ADRB3ENPP3ENPP1
SCHEMBL9440972 0.86 DHODH (0.44) DHODHADRB1ADRB3ENPP3ENPP1
SCHEMBL10711669 0.81 LTA4H (0.46) ENPP3ENPP1MEN1KMT2AHPGD
SCHEMBL6330452 0.80 ADRB1 (0.57) ADRB1ADRB3ENPP3ENPP1MEN1
SCHEMBL9440823 0.78 MEN1 (0.59) DHODHENPP3ENPP1MEN1KMT2A
SCHEMBL2756582 0.77 LTA4H (0.45) ADRB1ADRB3ENPP3LTA4HSMN1; SMN2
SCHEMBL10747798 0.74 LTA4H (0.44) ENPP3ENPP1LTA4HRAB9ANPC1
SCHEMBL202405 0.73 RAB9A (0.54) DHODHMEN1KMT2ALTA4HSMN1; SMN2
SCHEMBL4439697 0.73 TSHR (0.71) DHODHMEN1KMT2ASMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
CN-102008459-B Antibacterial agents BIOTA SCIENT MAN 2013-05-29 CN disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
CN-101404989-B Antibacterial agent PROLYSIS LTD 2011-10-05 CN disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
CN-102008459-A Antibacterial agents PROLYSIS LTD 2011-04-13 CN disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
CN-101404989-A Antibacterial agent PROLYSIS LTD (GB) 2009-04-08 CN disclosed
EP-1996180-A1 ANTIBACTERIAL AGENTS Prolysis Limited (GB) 2008-12-03 EP disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122918-A1 ANTIBACTERIAL AGENTS ALK, ROS1, ARG1 DHODH 1965/4885ADRB1 841/4885ADRB3 1724/4885
US-20130072520-A2 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 DHODH 1096/4885ADRB1 1032/4885ADRB3 1201/4885
US-20150191420-A1 ANTIBACTERIAL AGENTS ALK, ARG1, ROS1 DHODH 2178/4885ADRB1 803/4885ADRB3 1635/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 DHODH 1096/4885ADRB1 1032/4885ADRB3 1201/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 DHODH 1096/4885ADRB1 1032/4885ADRB3 1201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.