Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.30 |
| ▸ | TET3 | O43151 | 1/20 | 0.30 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL2013518 | 0.94 | CAMK2A (0.42) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL16665 | 0.89 | GPR84 (0.52) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL17240331 | 0.87 | GPR84 (0.56) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL136691 | 0.87 | GPR84 (0.56) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL157090 | 0.87 | GPR84 (0.56) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL17240335 | 0.87 | GPR84 (0.56) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL743707 | 0.87 | GPR84 (0.56) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL3682582 | 0.87 | GPR84 (0.56) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL890450 | 0.87 | GPR84 (0.56) | GPR84FFAR1FFAR4FNTAFNTB | |
| SCHEMBL139573 | 0.87 | GPR84 (0.56) | GPR84FFAR1FFAR4FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664289-B2 | Dye and coloring photosensitive composition | ADEKA CORPORATION (JP) | 2014-03-04 | — | — | US | disclosed |
| EP-2620476-A1 | PIGMENT AND COLORED PHOTOSENSITIVE COMPOSITION | Adeka Corporation (JP) | 2013-07-31 | — | — | EP | disclosed |
| US-20130041062-A1 | DYE AND COLORING PHOTOSENSITIVE COMPOSITION | ADEKA CORPORATION (JP) | 2013-02-14 | — | — | US | disclosed |
| US-8148045-B2 | Oxime ester compound and photopolymerization initiator containing the same | ADEKA CORPORATION (JP) | 2012-04-03 | — | — | US | disclosed |
| US-20110129778-A1 | OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING THE SAME | ADEKA CORPORATION (JP) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110129778-A1 | OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING THE SAME | OXER1, OR10J3, CDK11B | GPR84 1841/4885FFAR1 1792/4885FFAR4 1462/4885 |
| US-20130041062-A1 | DYE AND COLORING PHOTOSENSITIVE COMPOSITION | IK, CRY1, ABCG2 | GPR84 872/4885FFAR1 2284/4885FFAR4 3215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.