Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL2013642 | 0.94 | GPR84 (0.43) | CAMK2ATSHRTP53EGLN1EGLN3 | |
| SCHEMBL16091 | 0.89 | — | — | |
| SCHEMBL523411 | 0.89 | CAMK2A (0.52) | CAMK2ATSHRALOX15HSD17B10TBXAS1 | |
| Acrylic Acid SCHEMBL1411416 | 0.87 | ALOX15 (0.54) | CAMK2ATSHRALOX15HSD17B10TBXAS1 | |
| Maleic Acid SCHEMBL9502630 | 0.86 | TSHR (0.43) | TSHRTP53EGLN1EGLN3ALOX15 | |
| SCHEMBL3458521 | 0.84 | CAMK2A (0.48) | CAMK2AALOX15HSD17B10TBXAS1GPR84 | |
| SCHEMBL4866299 | 0.82 | TET2 (0.31) | TET2 | |
| Succinic Acid SCHEMBL2218294 | 0.82 | CAMK2A (0.59) | CAMK2ATSHREGLN1ALOX15HSD17B10 | |
| Acetone SCHEMBL8337322 | 0.82 | CAMK2A (0.46) | CAMK2AALOX15HSD17B10TBXAS1GPR84 | |
| SCHEMBL16665 | 0.81 | GPR84 (0.52) | CAMK2ATSHRALOX15HSD17B10TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10222721-B2 | Urethane foam and toner-conveying roller using the same | BRIDGESTONE CORPORATION (JP) | 2019-03-05 | — | — | US | disclosed |
| EP-2640756-B1 | MATERIALS HAVING CONTROLABLE DEGREE OF CROSSLINKING | EVONIK ROEHM GMBH (DE) | 2017-03-08 | — | — | EP | disclosed |
| US-9563154-B2 | Toner transfer roller and image forming device using the same | BRIDGESTONE CORPORATION (JP) | 2017-02-07 | — | — | US | disclosed |
| US-9316958-B2 | Charge-controlled polyurethane foam and toner-conveying roller using the same | BRIDGESTONE CORPORATION (JP) | 2016-04-19 | — | — | US | disclosed |
| US-8927071-B2 | Pressure-sensitive adhesive composition, pressure-sensitive adhesive and optical film | NIPPON CARBIDE INDUSTRIES CO., INC. (JP) | 2015-01-06 | — | — | US | disclosed |
| US-8148045-B2 | Oxime ester compound and photopolymerization initiator containing the same | ADEKA CORPORATION (JP) | 2012-04-03 | — | — | US | disclosed |
| EP-1496089-B1 | Antifouling coating | NIPPON PAINT CO LTD (JP) | 2011-11-02 | — | — | EP | disclosed |
| EP-1496088-B1 | Antifouling coating | NIPPON PAINT CO LTD (JP) | 2011-11-02 | — | — | EP | disclosed |
| US-20110236605-A1 | PRESSURE-SENSITIVE ADHESIVE COMPOSITION, PRESSURE-SENSITIVE ADHESIVE AND OPTICAL FILM | NIPPON CARBIDE INDUSTRIES CO., INC. (JP) | 2011-09-29 | — | — | US | disclosed |
| US-20110188900-A1 | URETHANE FOAM AND TONER-CONVEYING ROLLER USING THE SAME | BRIDGESTONE CORPORATION (JP) | 2011-08-04 | — | — | US | disclosed |
| US-20110177926-A1 | CHARGE-CONTROLLED POLYURETHANE FOAM AND TONER-CONVEYING ROLLER USING THE SAME | BRIDGESTONE CORPORATION (JP) | 2011-07-21 | — | — | US | disclosed |
| US-20110129778-A1 | OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING THE SAME | ADEKA CORPORATION (JP) | 2011-06-02 | — | — | US | disclosed |
| US-20100158579-A1 | TONER TRANSFER ROLLER AND IMAGE FORMING DEVICE USING THE SAME | BRIDGESTONE CORPORATION (JP) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110129778-A1 | OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING THE SAME | OXER1, OR10J3, CDK11B | CAMK2A 2224/4885TSHR 1146/4885TP53 3817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.