Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159149 | 0.85 | NR1H2 (0.49) | FAAH | |
| SCHEMBL23777734 | 0.79 | NOTUM (0.57) | FAAHNPC1NOTUMHTR1ARAB9A | |
| SCHEMBL27606539 | 0.78 | FAAH (0.54) | FAAHNPC1NOTUMGRM1CTSB | |
| SCHEMBL20139213 | 0.78 | FAAH (0.54) | FAAHNPC1NOTUMGRM1CTSB | |
| SCHEMBL20159148 | 0.74 | KHK (0.45) | RIPK1HTR1A | |
| SCHEMBL27564787 | 0.71 | GRM1 (0.67) | HTR1AGRM1CTSBCTSSCTSK | |
| SCHEMBL22466241 | 0.71 | HTR1A (0.49) | RIPK1HTR1A | |
| SCHEMBL4573827 | 0.70 | NPC1 (0.43) | FAAHNPC1NOTUMGRM1CHRM2 | |
| SCHEMBL30005676 | 0.70 | NOTUM (0.53) | FAAHNPC1NOTUMCHRM2CHRM1 | |
| SCHEMBL4585200 | 0.69 | CTSB (0.54) | FAAHCTSBCTSSCTSKCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |