Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.36 |
| ▸ | VCP | P55072 | 2/20 | 0.35 |
| ▸ | GHSR | Q92847 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL315161 | 0.76 | ADRB1 (0.63) | KHKMAPTADRB1ALDH1A1 | |
| SCHEMBL22466241 | 0.75 | HTR1A (0.49) | MAPTHTR1AVCPALDH1A1LMNA | |
| SCHEMBL8109027 | 0.75 | KHK (0.50) | KHKMAPTADRB1BCL2A1 | |
| SCHEMBL12892626 | 0.75 | HTR3E (0.61) | KHKMAPTHTR1AADRB1BCL2A1 | |
| SCHEMBL2245201 | 0.75 | HTR3E (0.61) | KHKMAPTHTR1AADRB1BCL2A1 | |
| SCHEMBL4240000 | 0.75 | HTR3E (0.61) | KHKMAPTHTR1AADRB1BCL2A1 | |
| SCHEMBL30208090 | 0.75 | HTR3E (0.61) | KHKMAPTHTR1AADRB1BCL2A1 | |
| SCHEMBL20139201 | 0.74 | FAAH (0.45) | HTR1ARIPK1 | |
| SCHEMBL2873025 | 0.73 | ADRB1 (0.65) | KHKMAPTHTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL20139242 | 0.73 | HTR3E (0.59) | KHKMAPTHTR1AADRB1BCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |