Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139908 | 0.84 | CTDSP1 (0.44) | GAAHDAC4SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL20161328 | 0.75 | SMN1; SMN2 (0.41) | GAASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL20139663 | 0.70 | ROCK2 (0.39) | GAAHDAC4KMT2AMEN1ALDH1A1 | |
| SCHEMBL30772894 | 0.67 | ALDH1A1 (0.48) | GAASMN1; SMN2KMT2AALDH1A1PKM | |
| SCHEMBL26122852 | 0.67 | ALDH1A1 (0.48) | GAASMN1; SMN2KMT2AALDH1A1PKM | |
| SCHEMBL6203371 | 0.67 | SMN1; SMN2 (0.40) | HDAC4SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL8745912 | 0.66 | NOTUM (0.40) | GAASMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL12877954 | 0.64 | HPGDS (0.45) | — | |
| SCHEMBL1433150 | 0.64 | SMN1; SMN2 (0.43) | GAASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL8745948 | 0.64 | POLB (0.39) | GAASMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538520-A2 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |