Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MC4R | P32245 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139640 | 0.84 | GAA (0.46) | GAAHDAC4SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL21775376 | 0.74 | CTDSP1 (0.44) | CTDSP1GAASLC6A9SMN1; SMN2MAPT | |
| SCHEMBL20141623 | 0.70 | HDAC4 (0.37) | GAAHDAC4SLC6A9CNR2 | |
| SCHEMBL17316873 | 0.65 | HDAC4 (0.49) | GAAHDAC4SLC6A9 | |
| SCHEMBL5403220 | 0.65 | CTDSP1 (0.49) | CTDSP1GAASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5530167 | 0.63 | MMP8 (0.49) | SMN1; SMN2ALDH1A1KDM4ETDP1CNR2 | |
| SCHEMBL11428004 | 0.63 | GPR35 (0.65) | GAASMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL16795580 | 0.63 | MMP8 (0.49) | SMN1; SMN2ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL15917866 | 0.62 | CASP1 (0.70) | GAASMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL28165643 | 0.62 | CES2 (0.53) | GAASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538520-A2 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |