Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 5/20 | 0.58 |
| ▸ | DRD2 | P14416 | 10/20 | 0.49 |
| ▸ | DRD4 | P21917 | 10/20 | 0.49 |
| ▸ | HTR1A | P08908 | 9/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139993 | 0.91 | DRD2 (0.54) | KDM5ADRD2DRD4HTR1AKCNH2 | |
| SCHEMBL1740301 | 0.88 | KDM5A (0.48) | KDM5ADRD2DRD4HTR1AKCNH2 | |
| SCHEMBL20140687 | 0.82 | KDM5A (0.53) | KDM5ADRD2DRD4HTR1AKCNH2 | |
| SCHEMBL20157283 | 0.82 | KDM5A (0.53) | KDM5ADRD2DRD4HTR1AKCNH2 | |
| SCHEMBL17672417 | 0.79 | KDM5A (0.47) | KDM5A | |
| SCHEMBL2806341 | 0.77 | HSD11B1 (0.60) | KDM5ADRD2DRD4 | |
| SCHEMBL20140593 | 0.76 | HTR1A (0.54) | DRD2DRD4HTR1AKCNH2 | |
| SCHEMBL27727712 | 0.76 | KDM4E (0.53) | KDM5AMAP4K4MAP3K12 | |
| SCHEMBL17820444 | 0.75 | PDE10A (0.43) | KDM5APDE10ACNR2 | |
| SCHEMBL17682618 | 0.75 | KDM5A (0.69) | KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |