Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141292 | 0.89 | BDKRB1 (0.47) | CHRM4CYP2C9CYP2C19HTR2BMAPK14 | |
| SCHEMBL20140782 | 0.85 | CHRM4 (0.44) | MAPTCHRM4MEN1KMT2ADRD4 | |
| SCHEMBL20139955 | 0.83 | KDM4E (0.52) | CHRM4DRD4DRD2ALDH1A1DRD3 | |
| SCHEMBL20156971 | 0.82 | CHRM4 (0.41) | MAPTCHRM4MEN1KMT2AHTT | |
| SCHEMBL20140897 | 0.80 | MTOR (0.45) | CYP2C9CYP2C19HTR2BMAPK14HTT | |
| SCHEMBL20129698 | 0.79 | MTOR (0.49) | CHRM4DRD4DRD2ALDH1A1DRD3 | |
| SCHEMBL20140648 | 0.76 | PRMT5 (0.42) | DRD4DRD2ALDH1A1DRD3KDM4E | |
| SCHEMBL20141103 | 0.75 | MYC (0.57) | MEN1KMT2AHTTSMN1; SMN2GFER | |
| SCHEMBL20140775 | 0.74 | DRD4 (0.51) | HTR2BMEN1KMT2ADRD4HTR2A | |
| SCHEMBL20129637 | 0.74 | MTOR (0.64) | CHRM4SMN1; SMN2DRD4DRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |