Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 6/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140733 | 0.89 | KDM4E (0.48) | PRMT5WDR77RETDRD4DRD2 | |
| SCHEMBL20140096 | 0.89 | PARP1 (0.45) | PRMT5WDR77DRD4DRD2DRD3 | |
| SCHEMBL20140667 | 0.86 | TRPC5 (0.42) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL20139955 | 0.84 | KDM4E (0.52) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL20157255 | 0.82 | MTOR (0.40) | KDM4EALDH1A1CYP46A1LMNAMTOR | |
| SCHEMBL20140336 | 0.76 | MAPT (0.47) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL20156995 | 0.76 | TRPC5 (0.46) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL20140725 | 0.76 | MTOR (0.47) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL20140513 | 0.76 | DRD4 (0.41) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL20139967 | 0.76 | NAMPT (0.48) | DRD4DRD2DRD3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |