Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.32 |
| ▸ | RELA | Q04206 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140446 | 0.92 | PTGIR (0.44) | PTGIRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL20140432 | 0.73 | CKS1B (0.45) | PTGIRSMN1; SMN2 | |
| SCHEMBL25731618 | 0.69 | CYP11B2 (0.47) | PTGIRSMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL18783623 | 0.68 | MEN1 (0.60) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL20140105 | 0.65 | CKS1B (0.44) | PTGIRSMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL10433136 | 0.65 | KDM5B (0.39) | SMN1; SMN2L3MBTL1TP53GABRG2GABRB3 | |
| SCHEMBL17044822 | 0.65 | LMNA (0.49) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL27996913 | 0.65 | PTGIR (0.49) | PTGIRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL30765074 | 0.64 | PSMB1 (0.45) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11491087 | 0.64 | PTGIR (0.79) | PTGIRSMN1; SMN2KMT2ALMNAKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |