Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 2/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140448 | 0.91 | PTGIR (0.38) | SMN1; SMN2KDM5AKDM4CKDM5BPTGIR | |
| SCHEMBL25731618 | 0.65 | CYP11B2 (0.47) | SMN1; SMN2PTGIRMAPTNPC1RAB9A | |
| SCHEMBL20140432 | 0.65 | CKS1B (0.45) | SMN1; SMN2PTGIR | |
| SCHEMBL20140430 | 0.63 | PTGIR (0.43) | SMN1; SMN2PTGIRMAPTNPC1RAB9A | |
| SCHEMBL21247485 | 0.61 | CNR1 (0.43) | SMN1; SMN2MAPTNPC1RAB9ACNR2 | |
| SCHEMBL27996913 | 0.61 | PTGIR (0.49) | SMN1; SMN2PTGIRMAPTNPC1RAB9A | |
| SCHEMBL9877332 | 0.61 | MAPT (0.54) | SMN1; SMN2PTGIRMAPTNPC1RAB9A | |
| SCHEMBL9877609 | 0.59 | SMN1; SMN2 (0.51) | SMN1; SMN2PTGIRMAPTNPC1RAB9A | |
| SCHEMBL23401005 | 0.58 | RAB9A (0.39) | SMN1; SMN2PTGIRMAPTNPC1RAB9A | |
| SCHEMBL27996599 | 0.58 | LPAR1 (0.64) | SMN1; SMN2PTGIRLPAR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |