Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140363 | 0.65 | CYP2D6 (0.34) | RORCHSD11B1APPCYP3A4CYP2C9 | |
| SCHEMBL4460820 | 0.64 | TNKS (0.41) | HSD11B1HTR2BTMEM97 | |
| SCHEMBL16422879 | 0.61 | DRD2 (0.45) | CYP3A4CYP2C9CYP2C19CYP2D6HTR2B | |
| SCHEMBL16423296 | 0.61 | CCR2 (0.40) | HSD11B1CYP3A4CYP2C19 | |
| SCHEMBL20140450 | 0.61 | RORC (0.72) | RORC | |
| SCHEMBL4926309 | 0.59 | SLC6A3 (0.45) | RORCHSD11B1 | |
| SCHEMBL4919417 | 0.59 | SLC6A3 (0.45) | RORCHSD11B1 | |
| SCHEMBL22776267 | 0.59 | TRPM8 (0.61) | CYP2D6 | |
| SCHEMBL22776026 | 0.59 | TRPM8 (0.61) | CYP2D6 | |
| SCHEMBL22776130 | 0.59 | TRPM8 (0.61) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538522-A1 | ROR GAMMA MODULATORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |