Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140426 | 0.72 | HTR6 (0.43) | HTR7HTR1A | |
| SCHEMBL20140471 | 0.65 | RORC (0.37) | CYP2D6HSD11B1RORCCYP3A4HDAC1 | |
| SCHEMBL24685649 | 0.64 | SIGMAR1 (0.46) | OPRM1DRD2MEN1KMT2A | |
| SCHEMBL10533047 | 0.62 | ALOX5AP (0.53) | DRD3TSHRHDAC2CYP2C9CYP2C19 | |
| SCHEMBL6926354 | 0.62 | OPRM1 (0.51) | CYP2D6OPRM1OPRD1DRD2KMT2A | |
| SCHEMBL9230998 | 0.61 | MAOB (0.43) | HSD11B1 | |
| SCHEMBL27099783 | 0.59 | OPRM1 (0.63) | EPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL24119449 | 0.59 | OPRM1 (0.63) | EPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL8931777 | 0.59 | OPRM1 (0.63) | EPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL10819384 | 0.59 | HSD11B1 (0.51) | HSD11B1OPRM1OPRD1OPRK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538522-A1 | ROR GAMMA MODULATORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |