Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159112 | 0.81 | MTOR (0.58) | KDM4EALDH1A1PRKAA2 | |
| SCHEMBL20140681 | 0.75 | ALDH1A1 (0.52) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL20140541 | 0.74 | MTOR (0.46) | ALDH1A1PRKAA2NPC1 | |
| SCHEMBL20156964 | 0.72 | MTOR (0.49) | KDM4EPRKAA2SMN1; SMN2HTTLMNA | |
| SCHEMBL20157415 | 0.71 | PPARG (0.42) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20159153 | 0.70 | MTOR (0.61) | PRKAA2 | |
| SCHEMBL20156970 | 0.70 | PRKAA2 (0.47) | MEN1KMT2APRKAA2 | |
| SCHEMBL20159019 | 0.70 | MTOR (0.59) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL20140010 | 0.70 | MTOR (0.44) | PRKAA2 | |
| SCHEMBL20140388 | 0.70 | MTOR (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |