Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140044 | 0.89 | MTOR (0.54) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140693 | 0.86 | HCRTR1 (0.49) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20157539 | 0.85 | MTOR (0.46) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20156931 | 0.84 | MTOR (0.51) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20157021 | 0.83 | SLC6A7 (0.46) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140600 | 0.82 | KDM4E (0.54) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140304 | 0.82 | GBA1 (0.44) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20156963 | 0.82 | GBA1 (0.45) | MTORRPTORMLST8PARP1PHGDH | |
| SCHEMBL20139909 | 0.81 | LMNA (0.52) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140587 | 0.81 | MTOR (0.54) | MTORRPTORMLST8PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |