Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 5/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157021 | 0.93 | SLC6A7 (0.46) | GBA1MTORRPTORMLST8PARP1 | |
| SCHEMBL20140660 | 0.89 | MTOR (0.48) | GBA1MTORRPTORMLST8PANK3 | |
| SCHEMBL20140044 | 0.88 | MTOR (0.54) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140693 | 0.87 | HCRTR1 (0.49) | GBA1MTORRPTORMLST8PARP1 | |
| SCHEMBL20140472 | 0.85 | PARP1 (0.46) | GBA1MTORRPTORMLST8PARP1 | |
| SCHEMBL20140785 | 0.85 | PARP1 (0.47) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140600 | 0.85 | KDM4E (0.54) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20156931 | 0.83 | MTOR (0.51) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20157212 | 0.83 | GBA1 (0.51) | GBA1KDM4EALDH1A1NPSR1DRD4 | |
| SCHEMBL20156927 | 0.83 | MTOR (0.47) | MTORRPTORMLST8PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |