Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16236014 | 0.82 | SLC6A7 (0.54) | SLC6A7HSD17B10CYP2D6ALDH1A1KDM4E | |
| SCHEMBL20141969 | 0.76 | IDO1 (0.35) | KDM4EKMT2A | |
| SCHEMBL25267550 | 0.74 | MEN1 (0.36) | CYP2D6ALDH1A1CYP2C19LMNASMN1; SMN2 | |
| SCHEMBL18759185 | 0.71 | MAPT (0.49) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL31713625 | 0.69 | GPR119 (0.52) | HSD17B10CYP2D6ALDH1A1CYP2C19SMN1; SMN2 | |
| SCHEMBL527703 | 0.69 | — | — | |
| SCHEMBL2856220 | 0.67 | GAA (0.61) | SLC6A7HSD17B10ALDH1A1KDM4ECYP2C19 | |
| SCHEMBL4589908 | 0.66 | PSMB5 (0.34) | — | |
| SCHEMBL15416474 | 0.65 | MEN1 (0.58) | HSD17B10CYP2D6ALDH1A1KDM4ECYP2C19 | |
| SCHEMBL21772136 | 0.65 | HSD11B1 (0.32) | ALDH1A1KDM4ELMNATSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |