Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589906 | 1.00 | PSMB5 (0.34) | PSMB5PSMB1NR1H2NR1H3GRM2 | |
| SCHEMBL20141795 | 0.69 | DGAT1 (0.32) | — | |
| SCHEMBL18759193 | 0.68 | GCK (0.39) | IDO1 | |
| SCHEMBL18759192 | 0.68 | GCK (0.39) | IDO1 | |
| SCHEMBL20141969 | 0.67 | IDO1 (0.35) | IDO1 | |
| SCHEMBL4573157 | 0.67 | SUV39H2 (0.47) | NR1H2NR1H3 | |
| SCHEMBL20140928 | 0.66 | SLC6A7 (0.42) | — | |
| SCHEMBL18759185 | 0.65 | MAPT (0.49) | — | |
| SCHEMBL8107811 | 0.63 | BCL2A1 (0.42) | PSMB5GRM2 | |
| SCHEMBL13522478 | 0.62 | POLB (0.44) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |