Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMO | Q99835 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141892 | 0.83 | PKM (0.47) | PKMPOLBSMOPPARGDCTPP1 | |
| SCHEMBL20141007 | 0.82 | PKM (0.48) | PKMPOLBSMOPPARGGPR119 | |
| SCHEMBL20141897 | 0.78 | HTT (0.47) | PKMPOLBPPARGPARP1KDM4E | |
| SCHEMBL20139969 | 0.72 | MTOR (0.49) | PARP1KDM4ELMNASMN1; SMN2GAA | |
| SCHEMBL20140521 | 0.71 | ALDH1A1 (0.44) | PKMPOLBL3MBTL1KDM4ELMNA | |
| SCHEMBL4728850 | 0.68 | PKM (0.56) | PKMPOLBMAPTALDH1A1 | |
| SCHEMBL14261619 | 0.68 | PKM (0.56) | PKMPOLBMAPTALDH1A1 | |
| SCHEMBL14087184 | 0.66 | HDAC3 (0.49) | PKMGPR119L3MBTL1KDM4ELMNA | |
| SCHEMBL15857987 | 0.65 | TDO2 (0.56) | GPR119L3MBTL1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL20804512 | 0.65 | ALDH1A1 (0.56) | PKML3MBTL1KDM4ESMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |